The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 26, 2020
Filed:
Jul. 29, 2016
The United States of America, As Represented BY the Secretary, Department of Health and Human Services, Bethesda, MD (US);
American International Biotechnology, Llc, Richmond, VA (US);
Trevor Lane Broadt, Frederick, MD (US);
Michael D. Harwich, Richmond, VA (US);
William T. Budd, Louisa, VA (US);
Gregory A. Meyers, Midlothian, VA (US);
The United States of America, as represented by the Secretary, Department of Health and Human Serv, Bethesda, MD (US);
American International Biotechnology, LLC, Richmond, VA (US);
Abstract
Described herein are massively parallel sequencing methods for virus-derived therapeutics such as viral vaccines, including the PVS-RIPO vaccine. The methods allow for the determination of micro-heterogeneity and quantitation of low frequency sequence variants and in the case of PVS-RIPO, are expected to replace the monkey neurovirulence safety test (MNVT) and the mutant analysis by PCR and restriction enzyme cleavage (MAPREC) methods that are currently used to screen lots of RNA virus-derived therapeutics.