The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 26, 2020
Filed:
Feb. 21, 2018
Arrowhead Pharmaceuticals, Inc., Pasadena, CA (US);
Stacey Melquist, Madison, WI (US);
Steven Kanner, Madison, WI (US);
David B. Rozema, Cross Plains, WI (US);
David L. Lewis, Madison, WI (US);
Lauren J. Almeida, Madison, WI (US);
Darren H. Wakefield, Fitchburg, WI (US);
Vladimir S. Trubetskoy, Middleton, WI (US);
Tao Pei, Middleton, WI (US);
Zhen Li, Monona, WI (US);
Aaron Almeida, Madison, WI (US);
Arrowhead Pharmaceuticals, Inc., Pasadena, CA (US);
Abstract
RNA interference (RNAi) agents and RNAi agent conjugates for inhibiting the expression of the LPA (apo(a)) gene are described. Pharmaceutical compositions comprising one or more LPA RNAi agents optionally with one or more additional therapeutics are also described. Delivery of the described LPA RNAi agents to liver cells in vivo provides for inhibition of LPA gene expression and treatment of cardiovascular and cardiovascular-related diseases.