The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 26, 2020
Filed:
Jan. 25, 2019
Applicant:
Transgene S.a., Illkirch Graffenstaden, FR;
Inventors:
Perrine Martin, Decines, FR;
Nathalie Silvestre, Ergersheim, FR;
Jean-Baptiste Marchand, Obernai, FR;
Assignee:
Transgene S.A., Illkirch Graffenstaden, FR;
Primary Examiner:
Int. Cl.
CPC ...
C12N 9/12 (2006.01); C12P 21/02 (2006.01); C12N 7/00 (2006.01); C07K 14/005 (2006.01); A61K 39/29 (2006.01); C12N 9/22 (2006.01); A61K 38/00 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C12N 9/1252 (2013.01); A61K 39/292 (2013.01); C07K 14/005 (2013.01); C12N 7/00 (2013.01); C12N 9/1276 (2013.01); C12N 9/22 (2013.01); C12P 21/02 (2013.01); C12Y 207/07007 (2013.01); C12Y 301/26004 (2013.01); A61K 38/00 (2013.01); A61K 2039/53 (2013.01); C07K 2319/02 (2013.01); C07K 2319/03 (2013.01); C07K 2319/40 (2013.01); C12N 2730/10122 (2013.01); C12N 2730/10134 (2013.01); C12N 2799/022 (2013.01); C12N 2799/023 (2013.01);
Abstract
The present invention relates to polymerase HBV mutant polypeptides comprising a mutated polymerase domain which is functionally disrupted for polymerase activity and fusion proteins comprising such polymerase mutant polypeptide. The present invention also relates to a nucleic acid molecule and an expression vector for expressing said polymerase mutant polypeptide as well as a composition which can be used for eliciting an immune response to HBV with the goal of providing a protective or therapeutic effect against HBV infection.