The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 26, 2020

Filed:

Apr. 04, 2016
Applicants:

Subdomain, Llc, Washington, DC (US);

Arcellx, Inc, Germantown, MD (US);

Inventors:

David William Lafleur, Washington, DC (US);

David M. Hilbert, Germantown, MD (US);

Assignees:

Subdomain LLC, Washington, DC (US);

Arcellx, Inc., Germantown, MD (US);

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C40B 40/10 (2006.01); C07K 16/28 (2006.01); C07K 14/435 (2006.01); A61K 9/00 (2006.01); A61K 38/17 (2006.01); C07K 14/705 (2006.01); C07K 16/10 (2006.01); G01N 33/574 (2006.01); A61K 38/00 (2006.01); A61P 35/00 (2006.01);
U.S. Cl.
CPC ...
C07K 16/2878 (2013.01); A61K 9/0019 (2013.01); A61K 38/1774 (2013.01); C07K 14/435 (2013.01); C07K 14/70575 (2013.01); C07K 16/1027 (2013.01); G01N 33/57484 (2013.01); A61K 38/00 (2013.01); A61K 38/1764 (2013.01); A61P 35/00 (2018.01); C07K 2317/24 (2013.01); C07K 2317/31 (2013.01); C07K 2318/20 (2013.01); C07K 2319/00 (2013.01); C07K 2319/035 (2013.01); C07K 2319/21 (2013.01); C07K 2319/41 (2013.01); C07K 2319/43 (2013.01); C40B 40/10 (2013.01); G01N 2333/70596 (2013.01);
Abstract

Provided herein are de novo binding domain containing polypeptides (DBDpp) that specifically bind a target of interest. Nucleic acids encoding the DBDpp, and vectors and host cells containing the nucleic acids are also provided. Libraries of DBDpp, methods of producing and screening such libraries and the DBDpp identified from such libraries and screens are also encompassed. Methods of making and using the DBDpp are additionally provided. Such uses include, without limitation, affinity purification, and diagnostic and therapeutic applications.


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