The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 26, 2020
Filed:
Jun. 12, 2018
Applicant:
Vertex Pharmaceuticals Incorporated, Boston, MA (US);
Inventors:
Sara Hadida-Ruah, La Jolla, CA (US);
Anna Hazlewood, San Diego, CA (US);
Peter Grootenhuis, San Diego, CA (US);
Fredrick Van Goor, San Diego, CA (US);
Ashvani Singh, San Diego, CA (US);
Jinglan Zhou, San Diego, CA (US);
Jason McCartney, Cardiff by the Sea, CA (US);
Assignee:
Vertex Pharmaceuticals Incorporated, Boston, MA (US);
Primary Examiner:
Int. Cl.
CPC ...
C07C 205/11 (2006.01); C07C 205/58 (2006.01); C07D 471/10 (2006.01); C07C 211/17 (2006.01); C07C 209/00 (2006.01); C07C 215/28 (2006.01); C07D 209/08 (2006.01); C07D 209/14 (2006.01); C07D 209/18 (2006.01); C07D 209/42 (2006.01); C07D 209/94 (2006.01); C07D 213/20 (2006.01); C07D 213/73 (2006.01); C07D 215/227 (2006.01); C07D 215/38 (2006.01); C07D 217/06 (2006.01); C07D 223/16 (2006.01); C07D 265/36 (2006.01); C07D 279/16 (2006.01); C07D 311/58 (2006.01); C07D 401/14 (2006.01); C07D 405/12 (2006.01); C07D 409/12 (2006.01); C07D 413/12 (2006.01); C07D 417/12 (2006.01); C07C 215/76 (2006.01); C07D 215/56 (2006.01); C07D 401/12 (2006.01); C07D 215/233 (2006.01); A61K 8/49 (2006.01); A61K 31/47 (2006.01); A61K 31/4709 (2006.01); A61K 45/06 (2006.01); C07C 215/78 (2006.01); C07C 217/84 (2006.01); C07D 209/12 (2006.01); C07D 209/20 (2006.01); A61K 31/136 (2006.01); A61K 31/265 (2006.01); A61K 31/352 (2006.01); A61K 31/404 (2006.01); A61K 31/4045 (2006.01); A61K 31/4747 (2006.01); A61K 31/55 (2006.01); C07C 219/34 (2006.01); G01N 33/566 (2006.01); G01N 33/487 (2006.01); G01N 33/50 (2006.01); G01N 33/68 (2006.01); C07C 217/80 (2006.01); C07C 229/52 (2006.01); A61K 31/04 (2006.01); A61K 31/27 (2006.01); A61K 31/277 (2006.01); A61K 31/403 (2006.01); A61K 31/44 (2006.01); A61K 31/472 (2006.01); A61K 31/538 (2006.01); A61K 31/5415 (2006.01); C07C 211/50 (2006.01); C07C 211/52 (2006.01); C07C 215/70 (2006.01); C07C 217/76 (2006.01); C07C 255/58 (2006.01); C07C 271/20 (2006.01); C07C 311/08 (2006.01); C07C 311/39 (2006.01); C07D 209/04 (2006.01); C07D 209/96 (2006.01); C07D 217/04 (2006.01);
U.S. Cl.
CPC ...
C07D 471/10 (2013.01); A61K 8/4926 (2013.01); A61K 31/04 (2013.01); A61K 31/136 (2013.01); A61K 31/265 (2013.01); A61K 31/27 (2013.01); A61K 31/277 (2013.01); A61K 31/352 (2013.01); A61K 31/403 (2013.01); A61K 31/404 (2013.01); A61K 31/4045 (2013.01); A61K 31/44 (2013.01); A61K 31/47 (2013.01); A61K 31/472 (2013.01); A61K 31/4709 (2013.01); A61K 31/4747 (2013.01); A61K 31/538 (2013.01); A61K 31/5415 (2013.01); A61K 31/55 (2013.01); A61K 45/06 (2013.01); C07C 205/11 (2013.01); C07C 205/58 (2013.01); C07C 209/00 (2013.01); C07C 211/17 (2013.01); C07C 211/50 (2013.01); C07C 211/52 (2013.01); C07C 215/28 (2013.01); C07C 215/70 (2013.01); C07C 215/76 (2013.01); C07C 215/78 (2013.01); C07C 217/76 (2013.01); C07C 217/80 (2013.01); C07C 217/84 (2013.01); C07C 219/34 (2013.01); C07C 229/52 (2013.01); C07C 255/58 (2013.01); C07C 271/20 (2013.01); C07C 311/08 (2013.01); C07C 311/39 (2013.01); C07D 209/04 (2013.01); C07D 209/08 (2013.01); C07D 209/12 (2013.01); C07D 209/14 (2013.01); C07D 209/18 (2013.01); C07D 209/20 (2013.01); C07D 209/42 (2013.01); C07D 209/94 (2013.01); C07D 209/96 (2013.01); C07D 213/20 (2013.01); C07D 213/73 (2013.01); C07D 215/227 (2013.01); C07D 215/233 (2013.01); C07D 215/38 (2013.01); C07D 215/56 (2013.01); C07D 217/04 (2013.01); C07D 217/06 (2013.01); C07D 223/16 (2013.01); C07D 265/36 (2013.01); C07D 279/16 (2013.01); C07D 311/58 (2013.01); C07D 401/12 (2013.01); C07D 401/14 (2013.01); C07D 405/12 (2013.01); C07D 409/12 (2013.01); C07D 413/12 (2013.01); C07D 417/12 (2013.01); G01N 33/48728 (2013.01); G01N 33/5035 (2013.01); G01N 33/566 (2013.01); G01N 33/6872 (2013.01); C07C 2601/14 (2017.05); C07C 2601/18 (2017.05); C07C 2602/10 (2017.05); C07C 2603/74 (2017.05); G01N 2333/705 (2013.01);
Abstract
The present invention relates to modulators of ATP-Binding Cassette ('ABC') transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator, compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.