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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10662174 B1

PDFFull Text
Date of Patent:
May. 26, 2020

Filed:

Jul. 14, 2017

Btk inhibitor

Applicants:

Hubei Bio-pharmaceutical Industrial Technological Institute Inc., Wuhan, CN;

Humanwell Healthcare (Group) Co., Ltd., Wuhan, CN;

Inventors:

Xuehai Wang, Wuhan, CN;

Chengde Wu, Wuhan, CN;

Yong Xu, Wuhan, CN;

Chunli Shen, Wuhan, CN;

Li'e Li, Wuhan, CN;

Guoping Hu, Wuhan, CN;

Yang Yue, Wuhan, CN;

Jian Li, Wuhan, CN;

Diliang Guo, Wuhan, CN;

Nengyang Shi, Wuhan, CN;

Lu Huang, Wuhan, CN;

Shuhui Chen, Wuhan, CN;

Ronghua Tu, Wuhan, CN;

Zhongwen Yang, Wuhan, CN;

Xuwen Zhang, Wuhan, CN;

Qiang Xiao, Wuhan, CN;

Hua Tian, Wuhan, CN;

Yanping Yu, Wuhan, CN;

Hailiang Chen, Wuhan, CN;

Wenjie Sun, Wuhan, CN;

Zhenyu He, Wuhan, CN;

Jie Shen, Wuhan, CN;

Jing Yang, Wuhan, CN;

Jing Tang, Wuhan, CN;

Wen Zhou, Wuhan, CN;

Jing Yu, Wuhan, CN;

Yi Zhang, Wuhan, CN;

Quan Liu, Wuhan, CN;

Assignee:

HUBEI BIO-PHARMACEUTICAL INDUSTRIAL TECHNOLOGICAL INSTITUTE, INC., Wuhan, CN;

Attorneys:

Westman, Champlin & Koehler, P.A.

Z. Peter Sawicki

Amanda M. Prose

Primary Examiner:

Emily A Bernhardt

Int. Cl.
CPC ...
C07D 487/04 (2006.01); A61K 31/5025 (2006.01); C07D 401/14 (2006.01); C07D 471/04 (2006.01); A61K 31/505 (2006.01); C07D 401/04 (2006.01); A61K 31/506 (2006.01); C07D 239/48 (2006.01); C07D 239/04 (2006.01); C07D 213/74 (2006.01); C07D 213/73 (2006.01); C07D 401/12 (2006.01); C07D 235/04 (2006.01); A61K 31/5383 (2006.01); A61K 31/496 (2006.01); C07D 231/54 (2006.01); C07D 251/12 (2006.01); C07D 403/02 (2006.01); C07D 473/32 (2006.01); C07D 498/02 (2006.01); A61K 31/366 (2006.01); A61K 31/52 (2006.01); C07C 13/04 (2006.01);
U.S. Cl.
CPC ...
C07D 401/14 (2013.01); A61K 31/496 (2013.01); A61K 31/505 (2013.01); A61K 31/506 (2013.01); A61K 31/5383 (2013.01); C07D 213/73 (2013.01); C07D 213/74 (2013.01); C07D 231/54 (2013.01); C07D 235/04 (2013.01); C07D 239/04 (2013.01); C07D 239/48 (2013.01); C07D 251/12 (2013.01); C07D 401/04 (2013.01); C07D 401/12 (2013.01); C07D 471/04 (2013.01); A61K 31/366 (2013.01); A61K 31/52 (2013.01); C07C 13/04 (2013.01);
Abstract

Provided are a series of BTK inhibitors, and specifically disclosed are a compound, pharmaceutically acceptable salt thereof, tautomer thereof or prodrug thereof represented by formula (I), (II), (III) or (IV).

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