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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10662159 B1

PDFFull Text
Date of Patent:
May. 26, 2020

Filed:

Nov. 21, 2018

Abhd6 and dual abhd6/mgl inhibitors and their uses

Applicant:

Makscientific, Llc, Burlington, MA (US);

Inventors:

Alexandros Makriyannis, Watertown, MA (US);

Michael Malamas, Jamison, PA (US);

Manjunath Lamani, Medford, MA (US);

Shrouq I. Farah, Everett, MA (US);

Assignee:

MAKSCIENTIFIC, LLC, Burlington, MA (US);

Attorney:

Hamilton, Brook, Smith & Reynolds, P.C.

Primary Examiner:

Kristin A Vajda

Int. Cl.
CPC ...
C07D 217/04 (2006.01); C07D 209/44 (2006.01); C07D 471/04 (2006.01); C07D 223/16 (2006.01); C07D 401/12 (2006.01); C07D 205/12 (2006.01); C07D 217/06 (2006.01); C07D 413/12 (2006.01); C07D 401/14 (2006.01); C07D 403/12 (2006.01);
U.S. Cl.
CPC ...
C07D 217/04 (2013.01); C07D 205/12 (2013.01); C07D 209/44 (2013.01); C07D 217/06 (2013.01); C07D 223/16 (2013.01); C07D 401/12 (2013.01); C07D 401/14 (2013.01); C07D 403/12 (2013.01); C07D 413/12 (2013.01); C07D 471/04 (2013.01);
Abstract

Provided herein are compounds and pharmaceutical compositions for selectively inhibiting serine hydrolase a/b-hydrolase domain 6 (ABHD6) and dually inhibiting ABHD6 and monoacylglycerol lipase (MGL). The compounds and pharmaceutical compositions disclosed herein are useful for treating a number of therapeutic conditions related to cannabinergic receptor function such as pain, inflammation, neuropathy, neurodegenerative diseases, anxiety disorders, motor function disorder, metabolic disorder, glaucoma and chemotherapy-induced nausea and vomiting and cancer.

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