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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10660928 B1

PDFFull Text
Date of Patent:
May. 26, 2020

Filed:

Mar. 08, 2017

Pharmaceutical composition containing combination extracts of moutan root bark, angelica dahurica root, bupleurum root or fractions thereof for prevention and treatment of neurodegenerative disorder

Applicants:

University-industry Cooperation Group of Kyung Hee University, Yongin-si, Gyeonggi-do, KR;

Dong-a St Co., Ltd., Seoul, KR;

Inventors:

Youngmi Kim, Seoul, KR;

Myung Sook Oh, Seoul, KR;

Seon-Pyo Hong, Seoul, KR;

Mi Won Sohn, Yongin-si, KR;

Jin Seok Jeong, Seoul, KR;

Hai Hua Jiang, Yongin-si, KR;

Eunjin Kim, Seoul, KR;

Ja Young Ryu, Seoul, KR;

Young Woong Cho, Suwon-si, KR;

Xiao Fei Du, Yongin-si, KR;

Sang Zin Choi, Suwon-si, KR;

Jeong Soo Kim, Yongin-si, KR;

Byoung Moon Kim, Seoul, KR;

Assignees:

UNIVERSITY-INDUSTRY COOPERATION GROUP OF KYUNG HEE UNIVERSITY, Yongin-si, KR;

DONG-A ST CO., LTD., Seoul, KR;

Attorney:

Lucas & Mercanti, LLP

Primary Examiner:

Amy L Clark

Int. Cl.
CPC ...
A61K 36/65 (2006.01); A61K 36/232 (2006.01); A61K 36/233 (2006.01); A23L 33/10 (2016.01); A23L 23/10 (2016.01); A23L 13/40 (2016.01); A23L 7/109 (2016.01); A21D 13/40 (2017.01); A21D 13/047 (2017.01); A23L 2/52 (2006.01); A61K 9/00 (2006.01); A61K 9/08 (2006.01); A61K 9/14 (2006.01); A61K 9/20 (2006.01); A61K 9/48 (2006.01); A61K 31/12 (2006.01); A61K 31/352 (2006.01); A61K 31/357 (2006.01); A61K 31/7048 (2006.01);
U.S. Cl.
CPC ...
A61K 36/65 (2013.01); A21D 13/047 (2017.01); A21D 13/40 (2017.01); A23L 2/52 (2013.01); A23L 7/109 (2016.08); A23L 13/422 (2016.08); A23L 23/10 (2016.08); A23L 33/10 (2016.08); A61K 9/0019 (2013.01); A61K 9/0056 (2013.01); A61K 9/0095 (2013.01); A61K 9/08 (2013.01); A61K 9/14 (2013.01); A61K 9/20 (2013.01); A61K 9/48 (2013.01); A61K 31/12 (2013.01); A61K 31/352 (2013.01); A61K 31/357 (2013.01); A61K 31/7048 (2013.01); A61K 36/232 (2013.01); A61K 36/233 (2013.01); A23V 2002/00 (2013.01); A61K 2236/333 (2013.01); A61K 2236/51 (2013.01); A61K 2236/53 (2013.01);
Abstract

The present invention relates to a pharmaceutical composition for treating and preventing degenerative neurological disorders, containing, as an active ingredient, a mixture extract of two or more types selected from the group consisting of Moutan Root Bark, Angelica Dahurica Root, and Bupleurum Root, or a fraction thereof. Specifically, the extract of the mixture of the present invention exhibits a recovery effect on mitochondrial function damage, a relieving effect on endoplasmic reticulum stress and also exhibits simultaneously an inhibitory effect on inflammatory response, which are remarkably improved compared with those exhibited in an in vitro single extract, and the extract of the mixture significantly exhibits an improvement effect on motor coordination and a protective effect on dopaminergic neurons in a Parkinson's disease animal model, and thus the extract of the mixture of the present invention or a fraction thereof can be useful as an active ingredient of a pharmaceutical composition for treating and preventing degenerative neurological disorders.

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