The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 26, 2020
Filed:
Feb. 22, 2019
Applicant:
University of South Florida, Tampa, FL (US);
Inventors:
Narasaiah Kolliputi, Tampa, FL (US);
Richard F. Lockey, Tampa, FL (US);
Lakshmi Galam, Tampa, FL (US);
Assignee:
University of South Florida, Tampa, FL (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/357 (2006.01); A61P 11/16 (2006.01); A61P 11/06 (2006.01); A61P 37/08 (2006.01);
U.S. Cl.
CPC ...
A61K 31/357 (2013.01); A61P 11/06 (2018.01); A61P 11/16 (2018.01); A61P 37/08 (2018.01);
Abstract
Methods of treating or preventing allergic or pulmonary diseases characterized by endothelial dysfunction with Alda-1 are presented. Treatment of pulmonary endothelial cells subjected to hyperoxia with Alda-1 showed an increase in ALDH2 activity and expression. Treatment with Alda-1 also illustrated a decrease in oxidative stress, a decrease in reactive oxygen species (ROS), a decrease in apoptosis, a decrease in inflammation and an enhancement of mitochondrial membrane potential.