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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10660860 B1

PDFFull Text
Date of Patent:
May. 26, 2020

Filed:

Feb. 08, 2018

Therapeutic cationic peptides and unimolecular nanoparticles for efficient delivery thereof

Applicant:

Wisconsin Alumni Research Foundation, Madison, WI (US);

Inventors:

Shaoqin Gong, Middleton, WI (US);

Wei Xu, Middleton, WI (US);

Yuyuan Wang, Madison, WI (US);

Fabao Liu, Madison, WI (US);

Assignee:

WISCONSIN ALUMNI RESEARCH FOUNDATION, Madison, WI (US);

Attorney:

Foley & Lardner LLP

Primary Examiner:

Kevin S Orwig

Int. Cl.
CPC ...
A61K 38/10 (2006.01); A61K 38/16 (2006.01); C07K 7/08 (2006.01); A61K 9/51 (2006.01); A61K 38/00 (2006.01); C07K 17/06 (2006.01); A61K 47/59 (2017.01); A61K 47/60 (2017.01);
U.S. Cl.
CPC ...
A61K 9/5146 (2013.01); A61K 9/513 (2013.01); A61K 38/005 (2013.01); A61K 38/10 (2013.01); A61K 47/595 (2017.08); A61K 47/60 (2017.08); C07K 7/08 (2013.01); C07K 17/06 (2013.01);
Abstract

Provided herein are peptides comprising an amino acid sequence having at least about 85% sequence identity to RYRPRAPIIAVT (SEQ ID NO: 1). These cationic peptides inhibit PKM2 methylation and may be used in the treatment of breast cancer and other diseases or conditions in which PKM2 is overexpressed. Such PKM2 peptides may be delivered to cancer cells using pH sensitive unimolecular nanoparticles comprising anionic polymers.

Find Patent Forward Citations

Gong, Shaoqin. (2020). Therapeutic cationic peptides and unimolecular nanoparticles for efficient delivery thereof (U.S. Patent No. 10660860). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/10660860

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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