The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 26, 2020
Filed:
Feb. 08, 2018
Applicant:
Wisconsin Alumni Research Foundation, Madison, WI (US);
Inventors:
Shaoqin Gong, Middleton, WI (US);
Wei Xu, Middleton, WI (US);
Yuyuan Wang, Madison, WI (US);
Fabao Liu, Madison, WI (US);
Assignee:
WISCONSIN ALUMNI RESEARCH FOUNDATION, Madison, WI (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/10 (2006.01); A61K 38/16 (2006.01); C07K 7/08 (2006.01); A61K 9/51 (2006.01); A61K 38/00 (2006.01); C07K 17/06 (2006.01); A61K 47/59 (2017.01); A61K 47/60 (2017.01);
U.S. Cl.
CPC ...
A61K 9/5146 (2013.01); A61K 9/513 (2013.01); A61K 38/005 (2013.01); A61K 38/10 (2013.01); A61K 47/595 (2017.08); A61K 47/60 (2017.08); C07K 7/08 (2013.01); C07K 17/06 (2013.01);
Abstract
Provided herein are peptides comprising an amino acid sequence having at least about 85% sequence identity to RYRPRAPIIAVT (SEQ ID NO: 1). These cationic peptides inhibit PKM2 methylation and may be used in the treatment of breast cancer and other diseases or conditions in which PKM2 is overexpressed. Such PKM2 peptides may be delivered to cancer cells using pH sensitive unimolecular nanoparticles comprising anionic polymers.