The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 26, 2020
Filed:
Sep. 16, 2016
Bionet Pharma Gmbh, Munich, DE;
Isabell Schoettle, Frankfurt am Main, DE;
Judith Stommes, Frankfurt am Main, DE;
Paul Habermann, Frankfurt am Main, DE;
Bernd Janocha, Frankfurt am Main, DE;
Ursula Stillger, Frankfurt am Main, DE;
Eckart Bartnik, Frankfurt am Main, DE;
Volker Jeske, Frankfurt am Main, DE;
Joachim Saas, Frankfurt am Main, DE;
BIONET PHARMA GMBH, Munich, DE;
Abstract
The present invention relates to a CD-RAP precursor protein comprising a pre-sequence and CD-RAP, and its use in manufacturing of native CD-RAP. The present invention further relates to a composition comprising CD-RAP and at least one positively charged amino acid and a buffer, pharmaceuticals comprising said composition, their use in methods of treating and/or preventing cartilage disease or injury in patients suffering from aggrecan degradation, and/or increased influx of water into the cartilage, and/or decreased CD-RAP expression, as well as methods of producing said composition and methods of storing CD-RAP in said composition. The present invention further relates to a composition comprising liposomes comprising encapsulated CD-RAP or a variant thereof, its use in methods of treating joint disease or injury, and methods of producing such liposomal composition as well as storing CD-RAP therein.