The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 26, 2020
Filed:
Sep. 19, 2014
Aarhus Universitet, Aarhus C, DK;
Kim Mouridsen, Hjortshøj, DK;
Mikkel Bo Hansen, Skanderborg, DK;
Irene Klærke Mikkelsen, Horsens, DK;
Susanne Lise Bekke, Solrød Strand, DK;
Birgitte Fuglsang Kjølby, Risskov, DK;
Aarhus Universitet, Aarhus C, DK;
Abstract
The present invention relates to a method for estimating perfusion indices (PI) in a mammal (), e.g. a human. Data (DAT, DAT') representative of a contrast agent concentration as a function of time of an injected contrast agent is obtained from a medical imaging system (). Perfusion indices (PI) are found by applying a parametric model (PM) for capillary transit time distributions as a function of time, and a minorize-maximization (MM) type procedure, such as an expectation-maximization (EM) type procedure, with regularization. The minorize-maximization type procedure has an exact analytical expression for the variance of an observation error of the contrast agent (C) in a non-linear observation model for the contrast agent concentration used in the maximization step. Clinical tests performed for 7 patients show improved MTT mapping as compared to singular value decomposition (SVD), and reduced sensitivity to delay.