The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 26, 2020
Filed:
Nov. 10, 2016
Applicant:
University of Leicester, Leicester, GB;
Inventors:
Teizo Fujita, Fukushima, JP;
Hans-Wilhelm Schwaeble, Mountsorrel, GB;
Cordula Margaret Stover, Wigston Meadows, GB;
Assignee:
University of Leicester, Leicester, GB;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A01K 67/00 (2006.01); C12N 15/85 (2006.01); A01K 67/027 (2006.01); C12N 9/64 (2006.01); C07K 16/28 (2006.01); C07K 16/40 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
A01K 67/0278 (2013.01); A01K 67/0276 (2013.01); C07K 16/2851 (2013.01); C07K 16/40 (2013.01); C12N 9/6424 (2013.01); C12N 15/8509 (2013.01); A01K 2207/15 (2013.01); A01K 2217/00 (2013.01); A01K 2217/072 (2013.01); A01K 2217/075 (2013.01); A01K 2227/105 (2013.01); A01K 2267/01 (2013.01); A01K 2267/03 (2013.01); A61K 38/00 (2013.01); C07K 2317/14 (2013.01); C12N 2510/00 (2013.01); C12N 2517/00 (2013.01); C12N 2800/30 (2013.01);
Abstract
Genetically modified mammals are described which lack the mannan binding lectin associated serine protease MASP-2, together with methods and constructs for their production. Such mammals are useful as models for disorders of the complement system, and in the identification of treatments for such disorders. Also described are mammals which lack the associated protein MAp19; such mammals may also lack MASP-2.