The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10656156 B1

PDF
Full Text
Expired
Date of Patent:
May. 19, 2020

Filed:

Jul. 05, 2012
Applicants:

Mepur H. Ravindranath, Los Angeles, CA (US);

Paul I. Terasaki, Los Angeles, CA (US);

Inventors:

Mepur H. Ravindranath, Los Angeles, CA (US);

Paul I. Terasaki, Los Angeles, CA (US);

Assignee:

Other;

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 39/00 (2006.01); C07K 16/28 (2006.01); G01N 33/574 (2006.01);
U.S. Cl.
CPC ...
G01N 33/57492 (2013.01); C07K 16/2833 (2013.01); C07K 2317/33 (2013.01); C07K 2317/34 (2013.01); C07K 2317/74 (2013.01); C07K 2317/76 (2013.01); G01N 2333/70539 (2013.01);
Abstract

Provided herein are compositions comprising purified antibodies and fragments thereof that are specifically immunoreactive to only human leukocyte antigen E (HLA-E) but not to other HLA Ia and HLA-Ib alleles. Also provided are methods of their making and diagnostic and therapeutic applications. The monospecific HLA-E antibodies are highly specific and can be used for diagnosing or localizing the presence of HLA-E on normal or diseased cells or tissues. The monospecific HLA-E antibodies can also be used for cancer therapies, likely through regulation of the CD94/NKG2a on Cytotoxic and/or Natural Killer T cells.


Find Patent Forward Citations

Ravindranath, Mepur. (2020). Diagnostic and therapeutic potential of hla-e monospecific monoclonal igg antibodies directed against tumor cell surface and soluble hla-e (U.S. Patent No. 10656156). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/10656156

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