The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 19, 2020
Filed:
Dec. 01, 2017
Immune profiling and minimal residue disease following stem cell transplantation in multiple myeloma
The Charlotte Mecklenburg Hospital Authority, Charlotte, NC (US);
Saad Z. Usmani, Charlotte, NC (US);
Manisha Bhutani, Charlotte, NC (US);
Qing Zhang, Charlotte, NC (US);
David M. Foureau, Matthews, NC (US);
The Charlotte Mecklenburg Hospital Authority, Charlotte, NC (US);
Abstract
The present invention provides methods for determining the level or status of minimal residue disease (MRD) in a multiple myeloma (MM) patient including analyzing peripheral natural killer (NK), NK-T and T cell distribution and/or activation, and quantifying inflammatory cytokines, chemokines and growth factors in a biological sample obtained from an MM patient to provide a peripheral immune profile; and obtaining a level or status of MRD in the MM patient from the peripheral immune profile, wherein if the peripheral immune profile exceeds a pre-determined threshold, the MM patient is positive for MRD.