The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 19, 2020
Filed:
Oct. 18, 2017
Applicant:
Geron Corporation, Menlo Park, CA (US);
Inventors:
Sergei Gryaznov, San Mateo, CA (US);
Krisztina Pongracz, Oakland, CA (US);
Assignee:
Geron Corporation, Menlo Park, CA (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/113 (2010.01); C12N 15/11 (2006.01); C07H 21/00 (2006.01);
U.S. Cl.
CPC ...
C12N 15/113 (2013.01); C07H 21/00 (2013.01); C12N 15/111 (2013.01); C12N 15/1132 (2013.01); C12N 15/1137 (2013.01); C12N 15/1138 (2013.01); C12N 2310/14 (2013.01); C12N 2310/3145 (2013.01); C12N 2310/3515 (2013.01); C12N 2320/51 (2013.01);
Abstract
The present disclosure relates to RNA amidates and thioamidates useful for RNA interference applications. The RNA amidates and thioamidates contain at least one internucleoside linkage chosen from ribo-N3'→P5′ phosphoramidate (NP) and ribo-N3′→P5′ thiophosphoramidate (NPS) linkages, and optionally further containing at least one covalently conjugated lipid moiety. Compositions comprising the amidates and thioamidates are disclosed, as are methods for their use in modulating gene expression.