The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 19, 2020

Filed:

Apr. 15, 2015
Applicant:

University of Virginia Patent Foundation, Charlottesville, VA (US);

Inventors:

Angela Zarling, Richmond, VA (US);

Victor H. Engelhard, Crozet, VA (US);

Kara L. Cummings, Charlottesville, VA (US);

Rebecca C. Obeng, Charlottesville, VA (US);

Assignee:

University of Virginia Patent Foundation, Charlottesville, VA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 14/725 (2006.01); A61K 38/17 (2006.01); A61K 39/00 (2006.01); G01N 33/566 (2006.01); G01N 33/574 (2006.01); A61K 38/19 (2006.01); G01N 33/50 (2006.01); G01N 33/569 (2006.01); A61K 35/17 (2015.01); A61K 47/64 (2017.01); A61K 45/06 (2006.01); C07K 16/28 (2006.01);
U.S. Cl.
CPC ...
C07K 14/7051 (2013.01); A61K 35/17 (2013.01); A61K 38/1774 (2013.01); A61K 38/19 (2013.01); A61K 39/0011 (2013.01); A61K 45/06 (2013.01); A61K 47/6425 (2017.08); C07K 16/2809 (2013.01); G01N 33/505 (2013.01); G01N 33/566 (2013.01); G01N 33/56977 (2013.01); G01N 33/574 (2013.01); G01N 33/57484 (2013.01); A61K 2039/5158 (2013.01); A61K 2039/55533 (2013.01); C07K 2317/76 (2013.01);
Abstract

Provided are isolated TCRs, TCR-like molecules, and portions thereof that bind to phosphopeptide-HLA-A2 complexes. The isolated TCRs, TCR-like molecules, or portions are optionally soluble TCRs, TCR-like molecules, or portions. Also provided are isolated nucleic acids encoding the disclosed TCRs, TCR-like molecules, or portions; host cells that contain the disclosed TCRs, TCR-like molecules, or portions; pharmaceutical compositions that include the disclosed TCRs, TCR-like molecules, portions, nucleic acids, and/or T cells; kits; and methods of using the same.


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