The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 19, 2020
Filed:
Oct. 19, 2017
Fundación Para LA Investigación Médica Aplicada, Pamplona, ES;
Inés Noelia Casares Lagar, Pamplona, ES;
Juan José Lasarte Sagastibelza, Pamplona, ES;
Teresa Lozano Moreda, Pamplona, ES;
Julen Oyarzabal Santamarina, Pamplona, ES;
Maria Obdulia Rabal Gracia, Pamplona, ES;
FUNDACIÓN PARA LA INVESTIGACIÓN MÉDICA APLICADA, Pamplona, ES;
Abstract
The present invention provides peptides of general formula (I) and salts thereof, wherein: Rand R, taken together, form a birradical linker; and R' is hydrogen; or, alternatively, Ris selected from hydrogen, —C(═O)—CH—NH—C(═O)—(C-C)alkyl, and —C(═O)—(C-C)alkyl; one of Rand R′ is hydrogen and the other is selected from —C(═O)NRR, and —C(═O)OH; and Rand Rare same or different and are selected from hydrogen and (C-C)alkyl. These peptides are highly efficient in binding and inhibiting FoxP3, being efficient in inhibiting and blocking Treg cell functionality, which make them useful in the treatment of cancer. The present invention also provides constructs comprising the peptide of formula (I) as well as combinations comprising the peptide of formula (I), the construct or both.