The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 19, 2020
Filed:
Sep. 15, 2017
Polytherics Limited, Cambridge, GB;
Nareshkumar Jain, Ringoes, NJ (US);
Sanjeevani Ghone, Plainsboro, NJ (US);
Sean Smith, Hamilton, NJ (US);
Ian Glassford, King of Prussia, PA (US);
Sylvia J. Degrado, Newtown, PA (US);
Fu-an Kang, Collegeville, PA (US);
Senzhi Zhao, Bensalem, PA (US);
POLYTHERICS LIMITED, Cambridge, GB;
Abstract
Provided herein are novel maytansinoid compounds of general formula I. Also provided herein are conjugates comprising the compounds linked to a binding protein via a linker, and conjugating reagents comprising the compounds attached via a linker to at least one functional group capable of reacting with a binding protein. Also provided herein are pharmaceutical compositions comprising the compounds and conjugates, therapeutic methods and uses involving the compounds and conjugates, for example in cancer therapy, and novel synthetic processes.