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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10654863 B1

PDFFull Text
Date of Patent:
May. 19, 2020

Filed:

Feb. 21, 2018

Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of hydrocodone, prodrugs, methods of making and use thereof

Applicant:

Kempharm, Inc., Coralville, IA (US);

Inventors:

Travis Mickle, Kissimmee, FL (US);

Sven Guenther, Coralville, IA (US);

Christal Mickle, Kissimmee, FL (US);

Guochen Chi, Coralville, IA (US);

Jaroslaw Kanski, Blacksburg, VA (US);

Andrea K. Martin, Fincastle, VA (US);

Bindu Bera, Blacksburg, VA (US);

Assignee:

KemPharm, Inc., Celebration, FL (US);

Attorney:

McAndrews, Held & Malloy, Ltd.

Primary Examiner:

Jennifer M Kim

Int. Cl.
CPC ...
A61K 31/485 (2006.01); C07D 489/02 (2006.01); A61K 47/54 (2017.01); A61K 9/20 (2006.01); A61K 47/55 (2017.01); A61P 25/30 (2006.01); A61K 47/48 (2006.01); A61K 45/06 (2006.01); C07D 491/08 (2006.01); C07D 489/04 (2006.01); A61K 31/167 (2006.01); A61K 9/00 (2006.01);
U.S. Cl.
CPC ...
C07D 489/02 (2013.01); A61K 9/0019 (2013.01); A61K 9/20 (2013.01); A61K 9/2054 (2013.01); A61K 31/167 (2013.01); A61K 31/485 (2013.01); A61K 45/06 (2013.01); A61K 47/48038 (2013.01); A61K 47/542 (2017.08); A61K 47/545 (2017.08); A61K 47/55 (2017.08); A61K 47/556 (2017.08); A61P 25/30 (2018.01); C07D 489/04 (2013.01); C07D 491/08 (2013.01); A61K 2300/00 (2013.01);
Abstract

The presently described technology provides methods of treating a patient having moderate to severe pain, narcotic or opioid abuse or narcotic or opioid withdrawal. The presently described methods are carried out by comprising administering to the patient a pharmaceutically effective amount of a composition comprising acetaminophen and benzoate-hydrocodone hydrochloride. The composition has reduced side effects when compared with unconjugated hydrocodone.

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