The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 19, 2020

Filed:

Jan. 13, 2016
Applicants:

The University of British Columbia, Vancouver, CA;

British Columbia Cancer Agency Branch, Vancouver, CA;

Inventors:

Raymond John Andersen, Vancouver, CA;

Javier Garcia Fernandez, Asturias, ES;

Kunzhong Jian, Vancouver, CA;

Marianne Dorothy Sadar, West Vancouver, CA;

Nasrin R. Mawji, Burnaby, CA;

Carmen Adriana Banuelos, Richmond, CA;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 249/04 (2006.01); A61K 45/06 (2006.01); C07D 233/60 (2006.01); A61K 31/4164 (2006.01); A61K 31/4192 (2006.01); A61K 31/5375 (2006.01); A61K 51/04 (2006.01); C07D 295/088 (2006.01); C07B 59/00 (2006.01); C07D 265/30 (2006.01); A61P 35/00 (2006.01); C07D 295/084 (2006.01);
U.S. Cl.
CPC ...
C07D 249/04 (2013.01); A61K 31/4164 (2013.01); A61K 31/4192 (2013.01); A61K 31/5375 (2013.01); A61K 45/06 (2013.01); A61K 51/0453 (2013.01); A61K 51/0459 (2013.01); A61K 51/0463 (2013.01); A61K 51/0465 (2013.01); A61P 35/00 (2018.01); C07B 59/002 (2013.01); C07D 233/60 (2013.01); C07D 265/30 (2013.01); C07D 295/084 (2013.01); C07D 295/088 (2013.01);
Abstract

Compounds having a structure of Formula I: or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R, R, R, R, R, R, R, X, n, n, and nare as defined herein, are provided. Uses of such compounds for modulating androgen receptor activity, imaging diagnostics in cancer and therapeutics, and methods for treatment of subjects in need thereof, including prostate cancer are also provided.


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