The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 19, 2020
Filed:
Aug. 28, 2015
Arbutus Biopharma Corporation, Burnaby, CA;
The University of British Columbia, Vancouver, CA;
Michael J. Hope, Vancouver, CA;
Sean C. Semple, Delta, CA;
Jianxin Chen, Vancouver, CA;
Thomas D. Madden, Vancouver, CA;
Pieter R. Cullis, Vancouver, CA;
Marco A. Ciufolini, Vancouver, CA;
Barbara Low Shoud Mui, Vancouver, CA;
THE UNIVERSITY OF BRITISH COLUMBIA, Vancouver, British Columbia, CA;
ARBUTUS BIOPHARMA CORPORATION, Burnaby, British Columbia, CA;
Abstract
The present invention provides superior compositions and methods for the delivery of therapeutic agents to cells. In particular, these include novel lipids and nucleic acid-lipid particles that provide efficient encapsulation of nucleic acids and efficient delivery of the encapsulated nucleic acid to cells in vivo. The compositions of the present invention are highly potent, thereby allowing effective knock-down of specific target proteins at relatively low doses. In addition, the compositions and methods of the present invention are less toxic and provide a greater therapeutic index compared to compositions and methods previously known in the art.