The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 19, 2020
Filed:
Oct. 14, 2016
Agios Pharmaceuticals, Inc., Cambridge, MA (US);
Celgene Corporation, Summit, NJ (US);
Samuel V. Agresta, Lexington, MA (US);
Krishnan Viswanadhan, East Hanover, NJ (US);
Jorge DiMartino, Belmont, CA (US);
Vivek Saroj Kumar Chopra, South San Francisco, CA (US);
Kyle J. MacBeth, San Francisco, CA (US);
Robert Douglas Knight, Berkeley Heights, NJ (US);
Laurie Kenvin, New Hope, PA (US);
Qiang Xu, Bernards, NJ (US);
Agios Pharmaceuticals, Inc., Cambridge, MA (US);
Celgene Corporation, Summit, NJ (US);
Abstract
Provided are methods and compositions for treating hematological malignancies in patients carrying an IDH1 mutation using a combination of an inhibitor of mutant IDH1 enzyme, (S)-N-((S)-1-(2-chlorophenyl)-2-((3,3-difluorocyclobutyl)amino)-2-oxoethyl)-1-(4-cyanopyridin-2-yl)-N-(5-fluoropyridin-3-yl)-5-oxopyrrolidine-2-carboxamide, or a pharmaceutically acceptable salt thereof (COMPOUND 2) and a DNA demethylating agent.