The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 19, 2020

Filed:

Aug. 04, 2015
Applicants:

Epizyme, Inc., Cambridge, MA (US);

Glaxosmithkline Intellectual Property Development Limited, Brentford, GB;

Inventors:

Kenneth W. Duncan, Westwood, MA (US);

Richard Chesworth, Concord, MA (US);

Paula Ann Boriack-Sjodin, Lexington, MA (US);

Michael John Munchhof, Salem, CT (US);

Lei Jin, Wellesley, MA (US);

Elayne Penebre, Auburndale, MA (US);

Olena I. Barbash, Collegeville, PA (US);

Assignees:

Epizyme, Inc., Cambridge, MA (US);

Glaxosmithkline Intellectual Property Development Limited, Brentford, Middlesex, GB;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/506 (2006.01); A61K 31/4725 (2006.01); A61K 31/513 (2006.01); A61P 35/00 (2006.01); A61K 45/06 (2006.01); G01N 33/574 (2006.01);
U.S. Cl.
CPC ...
A61K 31/506 (2013.01); A61K 31/4725 (2013.01); A61K 31/513 (2013.01); A61K 45/06 (2013.01); A61P 35/00 (2018.01); G01N 33/57496 (2013.01); G01N 2333/4748 (2013.01);
Abstract

Described herein are methods of treating cancer using one or more PRMT5 inhibitors, for example using one or more compounds of Formulae (1-5) or (A-F), pharmaceutically acceptable salts thereof, and/or pharmaceutical compositions thereof. Described herein are methods of treating cancer using one or more PRMT5 inhibitors, for example using one or more compounds of Formulae (1-5) or (A-F), pharmaceutically acceptable salts thereof, and/or pharmaceutical compositions thereof.


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