The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 19, 2020
Filed:
Nov. 03, 2016
Dana-farber Cancer Institute, Inc., Boston, MA (US);
The Brigham and Women's Hospital, Inc., Boston, MA (US);
Alan D. D'Andrea, Winchester, MA (US);
Gregory D. Cuny, Houston, TX (US);
Ross L. Stein, Cambridge, MA (US);
Marcie Glicksman, Winchester, MA (US);
April Case, Watertown, MA (US);
Jun Xian, Sharon, MA (US);
David Wilson, Lawrence, KS (US);
Min Huang, Shanghai, CN;
Dana-Farber Cancer Institute, Inc., Boston, MA (US);
The Brigham and Women's Hospital, Inc., Boston, MA (US);
Abstract
Provided are small molecule inhibitors of ubiquitin specific protease 1 (USP1) activity and methods for their use in treating and characterizing cancers. The small molecule USP1 inhibitors of the invention are particularly useful in the treatment of cancers that are resistant to DNA cross-linking agents.