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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10653648 B1

PDFFull Text
Date of Patent:
May. 19, 2020

Filed:

Jul. 20, 2017

Histone acetyltransferase activators and compositions and uses thereof

Applicant:

The Trustees of Columbia University IN the City of New York, New York, NY (US);

Inventors:

Owen Anthony O'Connor, Scarsdale, NY (US);

Jennifer Effie Amengual, Scarsdale, NY (US);

Donald W. Landry, New York, NY (US);

Ottavio Arancio, New York, NY (US);

Luigi Scotto, Stamford, CT (US);

Shixian Deng, White Plains, NY (US);

Rosa Purgatorio, New York, NY (US);

Jole Fiorito, New York, NY (US);

Assignee:

THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, New York, NY (US);

Attorney:

Wilmer Cutler Pickering Hale and Dorr LLP

Primary Examiner:

Shawquia Jackson

Int. Cl.
CPC ...
A61K 31/167 (2006.01); A61K 31/5377 (2006.01); A61K 31/44 (2006.01); A61K 31/381 (2006.01); A61K 45/06 (2006.01); A61K 31/535 (2006.01); A61K 31/4409 (2006.01); A61K 31/495 (2006.01); A61K 31/505 (2006.01); A61K 31/18 (2006.01); A61K 31/4035 (2006.01); A61K 31/4453 (2006.01); A61K 38/15 (2006.01);
U.S. Cl.
CPC ...
A61K 31/167 (2013.01); A61K 31/18 (2013.01); A61K 31/381 (2013.01); A61K 31/4035 (2013.01); A61K 31/44 (2013.01); A61K 31/4409 (2013.01); A61K 31/4453 (2013.01); A61K 31/495 (2013.01); A61K 31/505 (2013.01); A61K 31/535 (2013.01); A61K 31/5377 (2013.01); A61K 38/15 (2013.01); A61K 45/06 (2013.01);
Abstract

The invention provides pharmaceutical compositions and methods for treating cancer, neurodegenerative disorders, conditions associated with accumulated amyloid-beta peptide deposits, Tau protein levels, and/or accumulations of alpha-synuclein by administering a HAT modulator and a HDAC modulator to a subject.

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