The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 12, 2020
Filed:
Aug. 15, 2016
Applicant:
City of Hope, Duarte, CA (US);
Inventors:
Markus Kalkum, Azusa, CA (US);
Karine Bagramyan, North Hollywood, CA (US);
Diana Diaz-Arevalo, Monrovia, CA (US);
James I. Ito, La Verne, CA (US);
Sanjeet Dadwal, Duarte, CA (US);
Assignee:
CITY OF HOPE, Duarte, CA (US);
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A01N 37/18 (2006.01); A61K 38/00 (2006.01); A61K 38/16 (2006.01); A61K 38/10 (2006.01); A61K 38/08 (2019.01); A61K 38/07 (2006.01); A61K 38/04 (2006.01); A61P 31/10 (2006.01); A61K 39/00 (2006.01); A61K 39/42 (2006.01); C12P 21/08 (2006.01); G01N 33/53 (2006.01); G01N 33/573 (2006.01); C12Q 1/37 (2006.01); C07K 5/00 (2006.01); C07K 7/00 (2006.01); C07K 16/00 (2006.01); C07K 17/00 (2006.01); C07K 16/40 (2006.01); G01N 33/569 (2006.01); C07K 16/14 (2006.01); A61K 38/06 (2006.01); G01N 33/543 (2006.01); G01N 33/577 (2006.01);
U.S. Cl.
CPC ...
G01N 33/573 (2013.01); A61K 38/00 (2013.01); A61K 38/04 (2013.01); A61K 38/06 (2013.01); A61K 38/07 (2013.01); A61K 38/10 (2013.01); A61K 38/16 (2013.01); A61K 39/0002 (2013.01); C07K 16/14 (2013.01); C07K 16/40 (2013.01); C12Q 1/37 (2013.01); G01N 33/54313 (2013.01); G01N 33/56961 (2013.01); G01N 33/577 (2013.01); C07K 2317/622 (2013.01); C07K 2317/92 (2013.01); G01N 2333/38 (2013.01); G01N 2333/962 (2013.01);
Abstract
Provided herein are methods for detecting anprotease in a sample, diagnosing a subject with aspergillosis caused by aninfection based on the presence of anprotease in a sample, and methods of aspergillosis treatment that incorporate these diagnostic methods. In certain embodiments, theprotease is Asp f2, and theinfection is caused, or. Also provided herein are antibodies and kits for use in these methods, including novel antibodies specific for Asp f2.