The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 12, 2020
Filed:
Mar. 25, 2015
Applicant:
Genzyme Corporation, Cambridge, MA (US);
Inventors:
Kevin P. Brower, Holliston, MA (US);
Chris Hwang, Framingham, MA (US);
Rao Koduri, Shrewsbury, MA (US);
Konstantin B. Konstantinov, Waban, MA (US);
Veena Warikoo, Westford, MA (US);
Marcella Yu, Medford, MA (US);
Jin Yin, Somerville, MA (US);
Assignee:
GENZYME CORPORATION, Cambridge, MA (US);
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07K 1/113 (2006.01); A61K 39/395 (2006.01); C07K 16/28 (2006.01); C07K 16/00 (2006.01); C07K 16/22 (2006.01);
U.S. Cl.
CPC ...
C07K 16/2896 (2013.01); A61K 39/39591 (2013.01); C07K 1/1133 (2013.01); C07K 16/00 (2013.01); C07K 16/22 (2013.01); C07K 16/2839 (2013.01); C07K 2317/30 (2013.01); C07K 2317/52 (2013.01);
Abstract
Disclosed herein are methods that have been developed to control the formation of disulfide bonds between polypeptides of a multimeric protein produced by a bioprocess. Also disclosed are protein solution parameters that allow for controlling the formation of disulfide bonds. In one example, the methods disclosed herein can be used to control the proportion of half antibody molecules in an antibody solution.