The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 12, 2020
Filed:
Jun. 18, 2019
Abbvie S.à.r.l., Luxembourg, LU;
Galapagos NV, Mechelen, BE;
Rhalid Akkari, Pantin, FR;
Luke Jonathan Alvey, Versailles, FR;
Xavier Marie Bock, Romainville, FR;
Brian S. Brown, Evanston, IL (US);
Pieter Isabelle Roger Claes, Gentbrugge, BE;
Marlon D. Cowart, Round Lake Beach, IL (US);
Elsa De Lemos, Paris, FR;
Nicolas Desroy, Massy, FR;
Béranger Duthion, Paris, FR;
Gregory A. Gfesser, Lindenhurst, IL (US);
Romain Luc Marie Gosmini, Savigny-sur-Orge, FR;
Christopher Gaëtan Housseman, Montreuil, FR;
Koen Karel Jansen, Turnhout, BE;
Jianguo Ji, Libertyville, IL (US);
Philip R. Kym, Libertyville, IL (US);
Jean-Michel Lefrancois, Le Raincy, FR;
Oscar Mammoliti, Mechelen, BE;
Christel Jeanne Marie Menet, Brussels, BE;
Nuria Merayo Merayo, Paris, FR;
Gregory John Robert Newsome, Neuilly Plaisance, FR;
Adeline Marie Elise Palisse, Brussels, BE;
Sachin V. Patel, Round Lake, IL (US);
Matthieu Rafaël Pizzonero, Voisins le Bretonneux, FR;
Anurupa Shrestha, Vernon Hills, IL (US);
Elizabeth C. Swift, Highland Park, IL (US);
Steven Emiel Van der Plas, Steenhuffel, BE;
Xueqing Wang, San Carloa, CA (US);
Ann de Blieck, Mechelen, BE;
AbbVie S.á.r.l., Luxembourg, LU;
Galapagos NV, Mechelen, BE;
Abstract
The present invention provides for compounds of formula (I) wherein R, R, R, R, R, and Rhave any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions mediated and modulated by CFTR, including cystic fibrosis, Sjögren's syndrome, pancreatic insufficiency, chronic obstructive lung disease, and chronic obstructive airway disease. Also provided are pharmaceutical compositions comprised of one or more compounds of formula (I).