The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 12, 2020
Filed:
Nov. 14, 2017
St. Jude Children's Research Hospital, Memphis, TN (US);
R. Kiplin Guy, Memphis, TN (US);
Yiqun Zhang, Memphis, TN (US);
Brandon Young, Memphis, TN (US);
Michael Dyer, Memphis, TN (US);
Kristin Finch, Memphis, TN (US);
Donald Bashford, Memphis, TN (US);
Nagakumar Bharatham, Memphis, TN (US);
Richard Kriwacki, Memphis, TN (US);
Grace Royappa, Memphis, TN (US);
Lie Min, Memphis, TN (US);
Jaeki Min, Memphis, TN (US);
Antonio Ferreira, Memphis, TN (US);
St. Jude Children's Research Hospital, Memphis, TN (US);
Abstract
The compounds of the invention are antagonists of MDM2 and MDMX, with excellent specificity for MDM2 and MDMX over other proteins, and with selective binding affinity to MDMX over MDM2. The compounds can therefore regulate p53 activity and treat a variety of cancers. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.