Diphenylaminopyrimidine and triazine compound, and pharmaceutical composition and use thereof

Abstract

A diphenylaminopyrimidine and triazine compound of Formula I, or a pharmaceutically acceptable salt, stereoisomer, hydrate or solvate thereof is disclosed In formula I, A is C or N; X and Y are independently selected from hydrogen, halo, cyano, trifluoromethyl, alkoxy, alkyl, aryl, alkenyl, alkynyl and nitro; or X and Y, together with the atoms to which they are attached, form a phenyl or an heteroaromatic ring; Ris Ris CDor CDCD; Ris Ris hydrogen, methyl, trifluoromethyl, cyano or halo; Ris hydrogen, alkyl, substituted and unsubstituted phenyl, allyl or propargyl; Rand Rare independently selected from hydrogen, alkyl, substituted and unsubstituted phenyl, allyl and propargyl; or Rand R, together with the nitrogen atom to which they are attached, form a substituted or unsubstituted heterocycloalkyl group. The compound has pharmacodynamic and pharmacokinetic properties and ALK kinase inhibitory activity.