The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 12, 2020

Filed:

Sep. 14, 2016
Applicant:

Kaken Pharmaceutical Co., Ltd., Tokyo, JP;

Inventors:

Atsushi Watanabe, Kyoto, JP;

Yuuki Sato, Kyoto, JP;

Keiji Ogura, Kyoto, JP;

Yoshiyuki Tatsumi, Kyoto, JP;

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 213/643 (2006.01); C07D 401/14 (2006.01); C07D 405/14 (2006.01); C07D 413/14 (2006.01); C07D 401/12 (2006.01); C07D 239/34 (2006.01); C07D 417/14 (2006.01); C07D 471/04 (2006.01); C07D 498/04 (2006.01); C07D 213/65 (2006.01); A61K 31/535 (2006.01); A61K 31/444 (2006.01); A61K 31/5355 (2006.01); A61K 31/4709 (2006.01); C07D 241/18 (2006.01); C07D 213/64 (2006.01); A61K 31/4425 (2006.01); A61K 31/4725 (2006.01); A61K 31/4985 (2006.01); A61K 31/506 (2006.01); A61K 31/498 (2006.01); A61P 31/10 (2006.01); C07D 213/68 (2006.01); C07D 213/76 (2006.01); C07D 401/04 (2006.01); C07D 487/04 (2006.01); C07F 7/08 (2006.01);
U.S. Cl.
CPC ...
C07D 213/643 (2013.01); A61K 31/444 (2013.01); A61K 31/4425 (2013.01); A61K 31/4709 (2013.01); A61K 31/4725 (2013.01); A61K 31/498 (2013.01); A61K 31/4985 (2013.01); A61K 31/506 (2013.01); A61K 31/535 (2013.01); A61K 31/5355 (2013.01); A61P 31/10 (2018.01); C07D 213/64 (2013.01); C07D 213/65 (2013.01); C07D 213/68 (2013.01); C07D 213/76 (2013.01); C07D 239/34 (2013.01); C07D 241/18 (2013.01); C07D 401/04 (2013.01); C07D 401/12 (2013.01); C07D 401/14 (2013.01); C07D 405/14 (2013.01); C07D 413/14 (2013.01); C07D 417/14 (2013.01); C07D 471/04 (2013.01); C07D 487/04 (2013.01); C07D 498/04 (2013.01); C07F 7/0812 (2013.01);
Abstract

Provided is a compound showing excellent Antifungal activity againstfungus, which is a major causative microorganism of superficial mycosis, and high effectiveness on diseases caused byfungi. A biaryl derivative represented by the formula (I) or a salt thereof: wherein ring A is an optionally substituted phenyl, or an optionally substituted 5- or 6-membered ring heteroaryl (ring A may be further condensed to form an optionally substituted fused ring); Q is CH, C═O, NH, O, S or the like; X, Xand Xare CRor N; Y is CH or N; Z is CRor N; Rand Rare each a hydrogen atom, a halogen atom, an optionally substituted C-Calkyl group, a C-Chaloalkyl group or the like; Rand Rmay form, together with carbon atoms bonded thereto, an optionally substituted carbocycle, or an optionally substituted heterocycle.


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