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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10646616 B1

PDFFull Text
Date of Patent:
May. 12, 2020

Filed:

Apr. 28, 2017

Method for manufacturing bone-regeneration material comprising biodegradable fibers by using electrospinning method

Applicants:

National University Corporation Nagoya Institute of Technology, Nagoya-shi, Aichi, JP;

Orthorebirth Co.ltd., Yokohama-shi, Kanagawa, JP;

Inventors:

Toshihiro Kasuga, Nagoya, JP;

Yasutoshi Nishikawa, Yokohama, JP;

Assignees:

National University Corporation Nagoya Institute of Technology, Nagoya, JP;

Orthorebirth Co., Ltd., Yokohama, JP;

Attorney:

Liang Legal Group, PLLC

Primary Examiner:

Leo B Tentoni

Int. Cl.
CPC ...
B29B 7/10 (2006.01); B29B 7/12 (2006.01); B29B 7/14 (2006.01); B29B 7/38 (2006.01); B29B 7/40 (2006.01); B29B 7/42 (2006.01); B29B 7/84 (2006.01); C08G 63/08 (2006.01); C08J 3/20 (2006.01); A61L 27/18 (2006.01); A61L 27/58 (2006.01); D01F 6/62 (2006.01); D01D 5/08 (2006.01); A61L 27/46 (2006.01); D01F 1/02 (2006.01); A61L 27/56 (2006.01); D01D 5/00 (2006.01); A61L 27/12 (2006.01); A61L 27/54 (2006.01); D01D 1/02 (2006.01); D01F 1/10 (2006.01); B29B 13/00 (2006.01); C08K 3/32 (2006.01);
U.S. Cl.
CPC ...
A61L 27/18 (2013.01); A61L 27/12 (2013.01); A61L 27/46 (2013.01); A61L 27/54 (2013.01); A61L 27/56 (2013.01); A61L 27/58 (2013.01); B29B 7/845 (2013.01); C08J 3/201 (2013.01); D01D 1/02 (2013.01); D01D 5/0038 (2013.01); D01D 5/0046 (2013.01); D01D 5/08 (2013.01); D01F 1/02 (2013.01); D01F 1/10 (2013.01); D01F 6/62 (2013.01); D01F 6/625 (2013.01); A61L 2300/412 (2013.01); A61L 2400/06 (2013.01); A61L 2400/12 (2013.01); A61L 2430/02 (2013.01); B29B 2013/005 (2013.01); C08K 2003/325 (2013.01); D10B 2331/041 (2013.01); D10B 2401/12 (2013.01); D10B 2509/00 (2013.01); D10B 2509/06 (2013.01);
Abstract

A bone-regeneration material that contains calcium phosphate particles in biodegradable fibers of PLGA manufactured by electrospinning. A PLGA resin is heated in a kneader until the resin viscosity becomes 10to 10Pa·s. A powder of calcium phosphate fine particles is added while the blade is rotated. The mixture is kneaded by continuous rotation of the blade in the heated state to disperse the calcium phosphate fine particles to obtain a composite having calcium phosphate fine particles dispersed in the PLGA resin. The composite is dissolved by a solvent, and the PLGA resin is completely dissolved by agitation for a prescribed duration to prepare a spinning solution in which the calcium phosphate fine particles are dispersed. Electrospinning is performed on the spinning solution to manufacture biodegradable fibers having therein the calcium phosphate fine particles substantially uniformly dispersed.

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