The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 12, 2020
Filed:
Dec. 19, 2018
Hangzhou Dac Biotech Co., Ltd., Hangzhou, CN;
Sanxing Sun, Hangzhou, CN;
Robert Yongxin Zhao, Hangzhou, CN;
Xing Li, Hangzhou, CN;
Huihui Guo, Hangzhou, CN;
Junxiang Jia, Hangzhou, CN;
Hongsheng Xie, Hangzhou, CN;
Xiaomai Zhou, Hangzhou, CN;
Yuanyuan Huang, Hangzhou, CN;
Qingliang Yang, Hangzhou, CN;
Xiaotao Zhuo, Hangzhou, CN;
Hangbo Ye, Hangzhou, CN;
Shun Gai, Hangzhou, CN;
Lan Qu, Hangzhou, CN;
Wenjun Li, Hangzhou, CN;
Chen Lin, Hangzhou, CN;
HANGZHOU DAC BIOTECH CO., LTD., Hangzhou, CN;
Abstract
Hydrophilic linkers are useful for linking drugs to cell-binding ligands in ligand-drug conjugates, such as antibody-drug conjugates. The ligand-drug conjugate includes a cell-binding ligand capable of binding to a particular cell population, and a drug connected to the ligand by a hydrophilic linker. The hydrophilic linker includes one or more hydrophilic groups that render the linker hydrophilic. The hydrophilic linker may also include functional groups at the two termini for coupling to the drug and the cell-binding ligand respectively.