The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 12, 2020

Filed:

Jun. 08, 2017
Applicant:

Showa Denko K.k., Tokyo, JP;

Inventors:

Daisuke Yagyu, Chiba, JP;

Yuko Nakagami, Fujisawa, JP;

Ryota Niibayashi, Honjo, JP;

Eiko Kato, Tokyo, JP;

Assignee:

SHOWA DENKO K.K., Tokyo, JP;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/513 (2006.01); A61Q 19/02 (2006.01); A61Q 19/08 (2006.01); A61P 17/16 (2006.01); A61K 8/49 (2006.01);
U.S. Cl.
CPC ...
A61K 31/513 (2013.01); A61K 8/49 (2013.01); A61K 8/4953 (2013.01); A61P 17/16 (2018.01); A61Q 19/02 (2013.01); A61Q 19/08 (2013.01);
Abstract

The present invention provides an agent containing an orotic acid derivative that has high solubility in solvent and has superior physiological activity. The agent of the present invention is a melanin production inhibitor, whitening agent, fibroblast activator, collagen and/or elastin production promoter or wrinkle ameliorant containing as an active ingredient thereof an orotic acid derivative represented by the following general formula (1) or a salt thereof. In formula (1), R preferably represents a side chain of glutamic acid, glycine, histidine or aspartic acid. [In formula (1), R represents a side chain of a naturally-occurring amino acid and R may form, together with a nitrogen atom adjacent thereto through a single carbon atom, a hetero ring].


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