The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 05, 2020
Filed:
Jan. 13, 2017
Applicant:
University of Delaware, Newark, DE (US);
Inventors:
Eleftherios T. Papoutsakis, Newark, DE (US);
William Brian Whitaker, Wilmington, DE (US);
Robert Kyle Bennett, Elkton, MD (US);
Assignee:
University of Delaware, Newark, DE (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 1/32 (2006.01); C12R 1/15 (2006.01); C12R 1/19 (2006.01); C12N 9/04 (2006.01); C12N 15/52 (2006.01);
U.S. Cl.
CPC ...
C12N 1/32 (2013.01); C12N 9/0006 (2013.01); C12N 15/52 (2013.01); C12R 1/15 (2013.01); C12R 1/19 (2013.01); C12Y 101/01244 (2013.01);
Abstract
The present invention provides a non-naturally occurring microbe capable of growing in a medium comprising methanol, comprising a heterologous polynucleotide encoding a heterologous methanol dehydrogenase (MDH) derived from aorganism (Cor), wherein the MDH is expressed in the microbe, and wherein the MDH exhibits a Km of no more than 3 mM for methanol. Also provided are uses of the non-naturally occurring microbe for oxidizing methanol and producing a metabolite as well as the preparation of the non-naturally occurring microbe.