The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 05, 2020
Filed:
Oct. 05, 2018
Keio University, Tokyo, JP;
Genefrontier Corporation, Kashiwa, JP;
Akira Miyakoshi, Kashiwa, JP;
Mikiko Nakamura, Kashiwa, JP;
Kanehisa Kojoh, Kashiwa, JP;
Satsuki Mochizuki, Tokyo, JP;
Yasunori Okada, Tokyo, JP;
GeneFrontier Corporation, Kashiwa-shi, Chiba, JP;
Keio University, Tokyo, JP;
Abstract
The present invention provides an antibody that specifically binds to human aggrecanase, and inhibits enzymatic activity of the human aggrecanase. In one embodiment, aggrecanase is ADAMTS4. In one embodiment, the antibody recognizes a particular epitope in human ADAMTS4, and inhibits not only aggrecanase activity of human ADAMTS4 but also aggrecanase activity of human ADAMTS5. In addition, the present invention also provides use of said antibody in the prophylaxis or treatment of the progression of arthritis.