Pbd antibacterial agents

Abstract

The invention relates to pyrrolobenzodiazepines compounds (PBDs) and to pharmaceutically acceptable salts thereof, which are useful as medicaments, in particular, to treat bacterial infections. The PBDs are compounds of formula (I): and salts and solvates thereof; wherein: dotted lines indicates the optional presence of a double bond; X, X, X, Xand Xare connecting functional groups; L is Calkylene; R, Rand Rare independently selected from phenylene, cyclopentanylene, cyclohexanylene, 5- to 9-membered heteroarylene and 5- to 6-membered hetereocyclylene groups, and these groups are optionally substituted with up to three optional substituent groups; Ris selected from N(Calkyl)(Calkyl), 5- to 6-membered nitrogen-containing hetereocyclyl groups, a monosaccharide moiety and an amino monosaccharide moiety wherein these groups are optionally substituted; and Rand Reither together form a double bond, or are selected from H and OR, or Ris a prodrug moiety and Ris OR; m is 0 or 1; with the proviso that when Xis C(O)NH then the up to three optional substituents of Rare not selected from (CH2)-COR; with the proviso that when Xis (CH)O then Ris not phenylene, m is 1 and Ris not a 5- to 9-membered heteroarylene; and with the proviso that when Xis C(O)NH or NHC(O) that Rand/or Ris not 5- to 9-membered heteroarylene.