logo

For the Inventor, By the Inventor

The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10640495 B1

PDFFull Text
Date of Patent:
May. 05, 2020

Filed:

Jul. 06, 2016

Heterocycle derivatives having trka inhibitory activity

Applicant:

Shionogi & Co., Ltd., Osaka, JP;

Inventors:

Akira Yukimasa, Osaka, JP;

Kenichiroh Nakamura, Osaka, JP;

Masanao Inagaki, Osaka, JP;

Kazuya Kano, Osaka, JP;

Motohiro Fujiu, Osaka, JP;

Hiroki Yamaguchi, Osaka, JP;

Kayoko Hata, Osaka, JP;

Takatsugu Inoue, Osaka, JP;

Assignee:

Shionogi & Co., Ltd., Osaka, JP;

Attorney:

Sterne, Kessler, Goldstein & Fox P.L.L.C.

Primary Examiner:

Timothy R Rozof

Int. Cl.
CPC ...
C07D 405/14 (2006.01); C07D 405/12 (2006.01); A61K 31/4155 (2006.01); A61K 31/427 (2006.01); A61K 31/433 (2006.01); A61K 31/437 (2006.01); A61K 31/4439 (2006.01); A61K 31/454 (2006.01); A61K 31/506 (2006.01); A61K 31/519 (2006.01); C07D 231/38 (2006.01); C07D 403/14 (2006.01); C07D 413/14 (2006.01); C07D 417/14 (2006.01); C07D 471/04 (2006.01); C07D 487/04 (2006.01); C07D 487/08 (2006.01); C07D 491/048 (2006.01); C07D 491/056 (2006.01); C07D 491/08 (2006.01); C07D 491/107 (2006.01); C07D 498/04 (2006.01); C07F 7/18 (2006.01); A61K 31/422 (2006.01);
U.S. Cl.
CPC ...
C07D 405/14 (2013.01); A61K 31/4155 (2013.01); A61K 31/422 (2013.01); A61K 31/433 (2013.01); A61K 31/437 (2013.01); A61K 31/4439 (2013.01); A61K 31/454 (2013.01); A61K 31/506 (2013.01); A61K 31/519 (2013.01); C07D 231/38 (2013.01); C07D 403/14 (2013.01); C07D 405/12 (2013.01); C07D 413/14 (2013.01); C07D 417/14 (2013.01); C07D 471/04 (2013.01); C07D 487/04 (2013.01); C07D 487/08 (2013.01); C07D 491/048 (2013.01); C07D 491/056 (2013.01); C07D 491/08 (2013.01); C07D 491/107 (2013.01); C07D 498/04 (2013.01); C07F 7/1804 (2013.01);
Abstract

The present invention provides a compound having a TrkA inhibitory activity or a pharmaceutically acceptable salt thereof. The present invention relates to a compound represented by Formula (I): wherein -L- is —C(═X)—, or the like, —Z— is —NR—, or the like, —Z— is —NR—, or the like, B is substituted or unsubstituted aromatic carbocyclyl, or the like, Y is a single bond, or the like, the ring C is a substituted or unsubstituted aromatic heterocycle, or the like, Ris a hydrogen atom, or the like, and the group represented by is a group represented by Formula: or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition comprising the same.

Find Patent Forward Citations

Loading…