The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 05, 2020
Filed:
Sep. 29, 2017
Applicant:
Technische Universität Berlin, Berlin, DE;
Inventors:
Assignee:
TECHNISCHE UNIVERSITÄT BERLIN, Berlin, DE;
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 35/768 (2015.01); A61K 35/76 (2015.01); A61P 35/00 (2006.01); A61K 31/7105 (2006.01); C12N 7/00 (2006.01);
U.S. Cl.
CPC ...
A61K 35/768 (2013.01); A61K 31/7105 (2013.01); A61K 35/76 (2013.01); A61P 35/00 (2018.01); C12N 7/00 (2013.01); C12N 2770/32321 (2013.01); C12N 2770/32332 (2013.01); C12N 2770/32371 (2013.01);
Abstract
The present invention relates to a method for treating cancer in a subject in need thereof, comprising administering to said subject a therapeutically effective amount of a Coxsackie B3 group virus or a modified form thereof, wherein the cells of the cancer express a heparan sulfate (HS) receptor on their surface and the virus binds to said HS receptor, enters and accumulates in the cancer cells, whereby at least some cancer cells undergo viral lysis.