The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 05, 2020
Filed:
Oct. 02, 2017
Applicant:
Ocean University of China, Qingdao, CN;
Inventors:
Changlun Shao, Qingdao, CN;
Changyun Wang, Qingdao, CN;
Xiaofeng Mu, Qingdao, CN;
Rufang Xu, Qingdao, CN;
Assignee:
OCEAN UNIVERSITY OF CHINA, Qingdao, CN;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/4704 (2006.01); C07D 215/22 (2006.01); C07D 405/06 (2006.01); C12P 17/12 (2006.01); C12P 17/16 (2006.01); A61K 31/341 (2006.01); C12R 1/645 (2006.01);
U.S. Cl.
CPC ...
A61K 31/4704 (2013.01); A61K 31/341 (2013.01); C07D 215/22 (2013.01); C07D 405/06 (2013.01); C12P 17/12 (2013.01); C12P 17/16 (2013.01); C12N 2710/16063 (2013.01); C12R 1/645 (2013.01);
Abstract
The present invention provides alkaloids with formula I, II, III, IV, or V and their pharmaceutically acceptable salts, their preparation and their uses as antivirus drugs, for example, for treatment of HSV-1 infection. The alkaloids with formula I were isolated from the fermentation of marine fungussp. (TA01-33) by means of column chromatography, such as positive phase silica gel column chromatography, etc. Alkaloids with formula II, III, IV and V were semisynthesized from compounds with formula I.