The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Apr. 28, 2020

Filed:

Nov. 09, 2009
Applicants:

Martin Lehmann, Grenzach-Wyhlen, DE;

Hans-peter Hohmann, Loerrach, DE;

Dietmar Laudert, Schopfheim, DE;

Michael Hans, Schopfheim, DE;

Inventors:

Martin Lehmann, Grenzach-Wyhlen, DE;

Hans-Peter Hohmann, Loerrach, DE;

Dietmar Laudert, Schopfheim, DE;

Michael Hans, Schopfheim, DE;

Assignee:

DSM IP ASSETS B.V., Heerlen, NL;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12Q 1/68 (2018.01); C12P 25/00 (2006.01); C12N 15/52 (2006.01); C07K 14/32 (2006.01);
U.S. Cl.
CPC ...
C12P 25/00 (2013.01); C07K 14/32 (2013.01); C12N 15/52 (2013.01);
Abstract

The present invention provides an improved biotechnological production of riboflavin (also referred herein as vitamin B2) through modification in the operon containing the riboflavin biosynthetic genes (rib operon), in particular modifications of/in the leader sequences (rib leader) upstream of the corresponding riboflavin biosynthetic genes (rib operon). Furthermore, the present invention relates to genetically engineered microorganisms carrying said modified sequences, processes to generate said modified sequences/microorganisms and the use thereof for production of riboflavin.


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