The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 28, 2020
Filed:
Nov. 09, 2016
The Board of Trustees of the Leland Stanford Junior University, Stanford, CA (US);
Oregon Health & Science University, Portland, OR (US);
Sirika Pillay, Hayward, CA (US);
Jan Carette, Palo Alto, CA (US);
Michael Stewart Chapman, Lake Oswego, OR (US);
Nancy Meyer, Portland, OR (US);
Andreas Puschnik, Palo Alto, CA (US);
Omar Davulcu, Portland, OR (US);
The Board of Trustees of the Leland Stanford Junior University, Stanford, CA (US);
Oregon Health & Science University, Portland, OR (US);
Abstract
Compositions and methods are provided for modulating adeno-associated virus (AAV) infection. For example, compositions and methods are provided for enhancing permissiveness of a target cell to AAV infection (e.g., by increasing levels of AAVR (KIAA0319L) in the cell), for reducing permissiveness of a target cell to AAV infection (e.g., by reducing levels of AAVR in the cell), and for nucleic acid delivery (e.g., by (i) increasing permissiveness of a target cell to AAV infection, e.g., by increasing the amount of AAVR in the cell; and (ii) contacting the target cell with an AAV particle that includes a nucleic acid of interest). Also provided are screening methods and kits for practicing the methods of the disclosure.