The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 28, 2020
Filed:
Dec. 05, 2017
Applicant:
The General Hospital Corporation, Boston, MA (US);
Inventors:
Assignee:
The General Hospital Corporation, Boston, MA (US);
Primary Examiner:
Int. Cl.
CPC ...
C12N 7/00 (2006.01); C07K 14/525 (2006.01); A61K 35/763 (2015.01); A61K 38/19 (2006.01);
U.S. Cl.
CPC ...
C12N 7/00 (2013.01); A61K 35/763 (2013.01); A61K 38/19 (2013.01); C07K 14/525 (2013.01); C12N 2710/16632 (2013.01); C12N 2710/16642 (2013.01); C12N 2710/16671 (2013.01);
Abstract
Disclosed herein is a recombinant oncolytic virus comprising a nucleic acid sequence encoding tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). One such oncolytic virus is oHSV. One form of TRAIL contained within the oncolytic virus is a secreted form of TRAIL. Examples of various forms of oHSV and secreted TRAIL are disclosed therein. Also disclosed are host cells and therapeutic formulations comprising the recombinant oncolytic virus. Also disclosed are methods of treating cancer in a subject by administering a therapeutic formulation comprising the recombinant oncolytic virus to the subject.