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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10633432 B1

PDFFull Text
Date of Patent:
Apr. 28, 2020

Filed:

Jan. 23, 2017

Vc-car molecule and use thereof in removing hiv-1 infected cells

Applicant:

Shenzhen City of Regeneration Biological Pharmaceutical Technology Co., Ltd., Shenzhen, CN;

Inventors:

Hui Zhang, Guangdong, CN;

Bingfeng Liu, Guangdong, CN;

Fan Zou, Guangdong, CN;

Assignee:

Shenzhen City of Regeneration Biological Pharmaceutical Technology Co., Ltd., Shenzhen, CN;

Attorney:

JCIPRNET

Primary Examiner:

Barry A Chestnut

Int. Cl.
CPC ...
C07K 16/10 (2006.01); A61K 39/00 (2006.01); A61K 39/21 (2006.01); A61K 39/42 (2006.01); A61K 39/12 (2006.01); C07K 14/725 (2006.01); C07K 14/705 (2006.01); C12N 5/0783 (2010.01); C12N 7/00 (2006.01);
U.S. Cl.
CPC ...
C07K 16/1063 (2013.01); C07K 14/7051 (2013.01); C07K 14/70521 (2013.01); C07K 14/70578 (2013.01); C12N 5/0636 (2013.01); C12N 7/00 (2013.01); C07K 2317/622 (2013.01); C07K 2317/76 (2013.01); C07K 2319/02 (2013.01); C07K 2319/03 (2013.01); C07K 2319/30 (2013.01); C07K 2319/33 (2013.01); C12N 2501/2302 (2013.01); C12N 2501/2307 (2013.01); C12N 2740/16111 (2013.01);
Abstract

The present invention relates to a VC-CAR molecule and a use thereof in removing HIV-1 infected cells. The VC-CAR molecule is characterized by linking an HIV-1 broad-spectrum neutralizing antibody VRC01 sourced scFv sequence and an intracellular domain sequence of a conventional CAR molecule which are respectively used as extracellular and intracellular domains. A T cell modified by the VC-CAR molecule can be specifically activated and secrete a great number of cytotoxicity-related cytokines, so that lysis of a target cell can be powerfully mediated, and it can be better used for anti-infection adoptive immunotherapy.

Find Patent Forward Citations

Zhang, Hui. (2020). Vc-car molecule and use thereof in removing hiv-1 infected cells (U.S. Patent No. 10633432). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/10633432

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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