The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 28, 2020
Filed:
Nov. 17, 2017
Zhejiang Huahai Pharmaceutical Co., Ltd., Taizhou, CN;
Zhejiang Huahai Tiancheng Pharmaceuticals Co., Ltd., Taizhou, CN;
Zhejiang Huahai Licheng Pharmaceuticals Co., Ltd., Taizhou, CN;
Songqing Wang, Taizhou, CN;
Peng Dong, Taizhou, CN;
Yang Zheng, Taizhou, CN;
Quanjun Li, Taizhou, CN;
ZHEJIANG HUAHAI PHARMACEUTICAL CO., LTD., Taizhou, Zhejiang, CN;
ZHEIJIANG HUAHAI TIANCHENG PHARMACEUTICALS CO., LTD., Taizhou, Zhejiang, CN;
ZHEJIANG HUAHAI LICHENG PHARMACEUTICALS CO., LTD., Taizhou, Zhejiang, CN;
Abstract
A method for preparing a lisinopril intermediate is provided. The method includes: treating (R)-hydroxy-4-phenylbutyrate with sulfonyl chloride in an organic solvent in the presence of a base to obtain a solution of sulfonate; reacting the obtained solution with a salt of trifluoroacetyl lysine; and obtaining a N-[1-(S)-alkoxycarbonyl-3-phenylpropyl]-N-trifluoroacetyl-L-lysine by separating after the reaction is completed. The method provided has a shorter synthesis route, is easy to operate, has a low cost, and is suitable for industrial production.
Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile