The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Apr. 28, 2020

Filed:

Mar. 17, 2016
Applicant:

Givaudan SA, Vernier, CH;

Inventor:

Fridtjof Schröder, Hettlingen, CH;

Assignee:

GIVAUDAN S.A., Vernier, CH;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 307/92 (2006.01); C07C 29/48 (2006.01); C07C 35/36 (2006.01); C07C 67/293 (2006.01);
U.S. Cl.
CPC ...
C07C 29/48 (2013.01); C07C 35/36 (2013.01); C07C 67/293 (2013.01); C07D 307/92 (2013.01); C07C 2601/02 (2017.05); C07C 2602/28 (2017.05); Y02P 20/55 (2015.11);
Abstract

A method of selective conversion of Abienol, represented by formula 1, to Sclareodiol, represented by formula 2 by ozonolysis and subsequent reduction. The ozonolysis is carried out at temperatures above −60° C., preferably in nonhalogenated solvents. R is selected from H, acetals, aminals, optionally substituted alkyl groups, such as benzyl group, carboxylates such as acetates or formates, carbonates such as methyl or ethyl carbonates, carbamates, and any protecting group which can be attached to 1 and cleaved from 2, R' is selected from CH═CH, an alkyl moiety with C2-C20, e.g. CH—CH, or a cycloalkyl or polycycloalkyl moiety with C3-C20, e.g. cyclopropyl, optionally alkylated, respectively, and the wavy bond is depicting an unspecified configuration of the adjacent double bond between C2 and C3.


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