The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 28, 2020
Filed:
Aug. 04, 2017
Applicant:
The Regents of the University of California, Oakland, CA (US);
Inventors:
Chia-Yung Wu, San Francisco, CA (US);
James Onuffer, Alameda, CA (US);
Wendell A. Lim, San Francisco, CA (US);
Assignee:
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, Oakland, CA (US);
Primary Examiner:
Int. Cl.
CPC ...
A61K 35/17 (2015.01); A61K 47/68 (2017.01); C07K 14/705 (2006.01); C07K 16/18 (2006.01); C07K 16/28 (2006.01); C07K 14/725 (2006.01); C12N 9/90 (2006.01); C12N 9/14 (2006.01); C12N 5/0783 (2010.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
A61K 35/17 (2013.01); A61K 47/6891 (2017.08); C07K 14/705 (2013.01); C07K 14/7051 (2013.01); C07K 14/70521 (2013.01); C07K 14/70575 (2013.01); C07K 14/70578 (2013.01); C07K 16/18 (2013.01); C07K 16/2803 (2013.01); C07K 16/2866 (2013.01); C12N 5/0636 (2013.01); C12N 9/14 (2013.01); C12N 9/90 (2013.01); C12Y 502/01008 (2013.01); A61K 2039/505 (2013.01); C07K 2317/622 (2013.01); C07K 2319/00 (2013.01); C07K 2319/03 (2013.01); C07K 2319/20 (2013.01); C07K 2319/33 (2013.01); C07K 2319/74 (2013.01); C12N 2510/00 (2013.01);
Abstract
The present disclosure provides a heterodimeric, conditionally active chimeric antigen receptor (CAR), and a nucleic acid comprising a nucleotide sequence encoding the CAR. The present disclosure provides cells genetically modified to produce the CAR. A CAR of the present disclosure can be used in various methods, which are also provided.