The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 28, 2020
Filed:
Jan. 24, 2019
Carlos Batthyány, Montevideo, UY;
Gloria Virginia López, Montevideo, UY;
Carlos Escande, Montevideo, UY;
Williams Arturo Porcal Quinta, Montevideo, UY;
Germán Adrian Galliussi López, Montevideo, UY;
Marcelo Hill, Canelones, UY;
Mercedes Segovia, Canelones, UY;
Carlos Batthyány, Montevideo, UY;
Gloria Virginia López, Montevideo, UY;
Carlos Escande, Montevideo, UY;
Williams Arturo Porcal Quinta, Montevideo, UY;
Germán Adrian Galliussi López, Montevideo, UY;
Marcelo Hill, Canelones, UY;
Mercedes Segovia, Canelones, UY;
Other;
Abstract
Current therapeutic approach to treating heart allotransplantation rejection focus on immunosuppression protocols that carry harmful side effects after chronic use, which include global immune depression to the patient. The present inventors have discovered alternative and synergistic protocols based on inhibiting NF-κB and NLRP3 inflammasome-dependent IL-1β release with nitrated NSAID derivatives.