The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 28, 2020
Filed:
Dec. 11, 2017
Applicant:
Hoffmann-la Roche Inc., Little Falls, NJ (US);
Inventors:
Johannes Aebi, Basel, CH;
Alexander Flohr, Basel, CH;
Juillerat-Jeanneret Lucienne, Lausanne, CH;
Golshayan Dela, Lausanne, CH;
Assignee:
Hoffmann-La Roche Inc., Little Falls, NJ (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/553 (2006.01); C07D 267/14 (2006.01); A61K 47/64 (2017.01);
U.S. Cl.
CPC ...
A61K 31/553 (2013.01); A61K 47/64 (2017.08); C07D 267/14 (2013.01);
Abstract
The instant invention relates to novel conjugates of the compound of formula (I):S—L—A  (I)or salts thereof, wherein A is a γ-secretase inhibitor, L is a linker and S is a peptidase-specific substrate, as well as processes for their manufacture, pharmaceutical compositions comprising them, and their use as medicaments.